Journal: Neuroscience and biobehavioral reviews

Article Title: Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review

doi: 10.1016/j.neubiorev.2022.104831

Figure Lengend Snippet: Summary of the effect of psychotropic substances on ocular parameters, stratified by substance type (reverse chronological order).

Article Snippet: Allman et al. (2010) , • D-amphetamine (0.3 mg/kg), oral gel cap , Antisaccade: • Errors (% saccades towards target) • Latency • Standard deviation of latency Predictive saccades: • % predictive saccades • Latency • Latency reflective saccades , • Infrared pupil tracker (250 Hz; Eyelink, SR Research, Mississauga, ON, Canada) • Analysis performed using semi-automated custom software package (SR Research, Osgoode, ON, Canada). , Antisaccade: ○ d -amphetamine decreased errors ↑a * ○ d -amphetamine decreased latency for those with long baseline latency ↑a * ○ d -amphetamine increased latency for those with short baseline latency ↓ ○ Group×order× drug interaction showed that among those who received placebo first, the short-latency group had longer latencies on drug, while the long latency group had shorter latencies on drug. ○ d -amphetamine ↔ standard deviation of latency Predictive saccades: ○ d -amphetamine ↔% predictive saccades ○ d -amphetamine ↔ latency ○ Main effect of group (long vs short baseline performer) on latency reflective saccades. , D-amphetamine reduced antisaccade error rates in healthy controls irrespective of baseline performance, replicating and extending findings with dopamine agonists in clinical populations. D-amphetamine showed baseline-dependent effects on antisaccade latency as a function of baseline latency, consistent with an inverted-U relationship between performance and dopamine activity..

Techniques: Activity Assay, Control, Software, Sampling, Amplification, Concentration Assay, Biomarker Discovery, Produced, Generated, Standard Deviation, Transmission Assay, Expressing, Functional Assay, Clinical Proteomics, Imaging, Injection, Marker, Inhibition